When inflammatory stressors dramatically change, disease phenotypes may transform between autoimmune hematopoietic failure and myeloid neoplasms

XC Zhao, B Ju, NN Xiu, XY Sun, FJ Meng - Frontiers in Immunology, 2024 - frontiersin.org
Aplastic anemia (AA) and hypoplastic myelodysplastic syndrome are paradigms of
autoimmune hematopoietic failure (AHF). Myelodysplastic syndrome and acute myeloid …

Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics

J Homolak - Advances in Protein Chemistry and Structural Biology, 2023 - Elsevier
Neurodegenerative diseases are a group of age-related disorders characterized by a
chronic and progressive loss of function and/or structure of synapses, neurons, and glial …

A powerful machine learning approach to identify interactions of differentially abundant gut microbial subsets in patients with metastatic and non-metastatic pancreatic …

A Villani, A Fontana, C Panebianco, C Ferro… - Gut …, 2024 - Taylor & Francis
Pancreatic cancer has a dismal prognosis, as it is often diagnosed at stage IV of the disease
and is characterized by metastatic spread. Gut microbiota and its metabolites have been …

Advances in the role of gut microbiota in the regulation of the tumor microenvironment

T Xinyuan, Y Lei, S Jianping… - Oncology …, 2023 - spandidos-publications.com
As a protector of human health, the gut microbiota plays an important role in the
development of the immune system during childhood, and the regulation of dietary habits …

Targeted isolation and AI-based analysis of edible fungal polysaccharides: Emphasizing tumor immunological mechanisms and future prospects as mycomedicines

T Li, Q Wang, C Rui, L Ren, M Dai, Y Bi… - International Journal of …, 2024 - Elsevier
Edible fungal polysaccharides have emerged as significant bioactive compounds with
diverse therapeutic potentials, including notable anti-tumor effects. Derived from various …

Path to bacteriotherapy: From bacterial engineering to therapeutic perspectives

J Liu, C He, W Tan, JH Zheng - Life Sciences, 2024 - Elsevier
The major reason for the failure of conventional therapies is the heterogeneity and
complexity of tumor microenvironments (TMEs). Many malignant tumors reprogram their …

Oral–Gut–Estrobolome Axis May Exert a Selective Impact on Oral Cancer

M Tatullo, J Nor, G Orrù, A Piattelli… - Journal of Dental …, 2024 - journals.sagepub.com
A subset of bacterial species that holds genes encoding for β-glucuronidase and β-
galactosidase, enzymes involved in the metabolism of conjugated estrogens, is called the …

[HTML][HTML] Adipose-Derived Stromal Cells and Cancer-Associated Fibroblasts: Interactions and Implications in Tumor Progression

RSA El Alaa, W Al-Mannai, N Darwish… - International Journal of …, 2024 - mdpi.com
Adipose-derived stromal cells (ASCs) and cancer-associated fibroblasts (CAFs) play pivotal
roles in the tumor microenvironment (TME), significantly influencing cancer progression and …

Gut Bacteria Provide Genetic and Molecular Reporter Systems to Identify Specific Diseases

LMT Dicks - International Journal of Molecular Sciences, 2024 - mdpi.com
With genetic information gained from next-generation sequencing (NGS) and genome-wide
association studies (GWAS), it is now possible to select for genes that encode reporter …

The Gut Microbiome as a Biomarker and Therapeutic Target in Hepatocellular Carcinoma

B Gok Yavuz, S Datar, S Chamseddine, YI Mohamed… - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is the most common type of liver cancer,
accounting for approximately 85–90% of all cases of liver cancer worldwide. The gut …