In theory, in vitro and in vivo models for human gliomas have great potential to not only
enhance our understanding of glioma biology, but also to facilitate the development of novel …

Antiangiogenic drugs targeting the VEGF pathway have slowed metastatic disease
progression in some patients, leading to progression-free survival (PFS) and overall survival …

PURPOSE: Synchrotron microbeam radiation therapy (MRT) relies on spatial fractionation of
the incident photon beam into parallel micron-wide beams. Our aim was to analyze the …

Despite advances in understanding of the molecular pathogenesis of glioma, outcomes
remain dismal. Developing successful treatments for glioma requires faithful in vivo disease …

Simple Summary Glioblastoma multiforme is the most lethal form of brain cancer. To improve
patient outcomes, more effective treatments should be designed. Therefore, it is important to …

Aptamers are single-stranded DNA or RNA oligonucleotides that assume specific 3D
structures and bind to target molecules with high affinity. The unique specificity of aptamers …

Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, whose effect
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …

Glioblastoma (GBM) is the most lethal primary brain tumor of the central nervous system in
adults. Despite advances in surgical and medical neuro-oncology, the median survival is …

Since nanocarriers such as liposomes are known to accumulate in tumors of tumor-bearing
animals, and those that have entrapped a positron emitter can be used to image a tumor by …

Purpose: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor that is radio-
resistant and recurs despite aggressive surgery, chemo, and radiotherapy. Autotaxin (ATX) …