Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Nucleic acid tests for clinical translation

M Li, F Yin, L Song, X Mao, F Li, C Fan, X Zuo… - Chemical …, 2021 - ACS Publications
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

Clustered regularly interspaced short palindromic repeats/Cas9-mediated lateral flow nucleic acid assay

X Wang, E Xiong, T Tian, M Cheng, W Lin, H Wang… - ACS …, 2020 - ACS Publications
The lateral flow assay is one of the most convenient analytical techniques for analyzing the
immune response, but its applicability to precise genetic analyses is limited by the false …

Gold nanoparticle-based colorimetric biosensors

H Aldewachi, T Chalati, MN Woodroofe, N Bricklebank… - Nanoscale, 2018 - pubs.rsc.org
Gold nanoparticles (AuNPs) provide excellent platforms for the development of colorimetric
biosensors as they can be easily functionalised, displaying different colours depending on …

[HTML][HTML] Tailoring noble metal nanoparticle designs to enable sensitive lateral flow immunoassay

X Chen, L Ding, X Huang, Y Xiong - Theranostics, 2022 - ncbi.nlm.nih.gov
Lateral flow immunoassay (LFIA) with gold nanoparticles (AuNPs) as signal reporters is a
popular point-of-care diagnostic technique. However, given the weak absorbance of …

Isothermal amplification of nucleic acids

Y Zhao, F Chen, Q Li, L Wang, C Fan - Chemical reviews, 2015 - ACS Publications
Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

Plasmon-enhanced optical sensors: a review

M Li, SK Cushing, N Wu - Analyst, 2015 - pubs.rsc.org
Surface plasmon resonance (SPR) has found extensive applications in chemi-sensors and
biosensors. Plasmons play different roles in different types of optical sensors. SPR …

Advances in paper-based point-of-care diagnostics

J Hu, SQ Wang, L Wang, F Li… - Biosensors and …, 2014 - Elsevier
Advanced diagnostic technologies, such as polymerase chain reaction (PCR) and enzyme-
linked immunosorbent assay (ELISA), have been widely used in well-equipped laboratories …

Replacing antibodies with aptamers in lateral flow immunoassay

A Chen, S Yang - Biosensors and bioelectronics, 2015 - Elsevier
Aptamers have been identified against various targets as a type of chemical or nucleic acid
ligand by systematic evolution of ligands by exponential enrichment (SELEX) with high …

Gold nanoparticles in chemical and biological sensing

K Saha, SS Agasti, C Kim, X Li, VM Rotello - Chemical reviews, 2012 - ACS Publications
1. INTRODUCTION Detection of chemical and biological agents plays a fundamental role in
biomedical, forensic and environmental sciences 1− 4 as well as in anti bioterrorism …