Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure,
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …

Reactive oxygen species (ROS) ubiquitously exist in mammalian cells to participate in
various cellular signaling pathways. The intracellular ROS levels are dependent on the …

Recreating the extracellular matrix organization and cellular patterns of anisotropic tissues
in bioengineered constructs remains a significant biofabrication challenge. Magnetically …

No consensus exists on how to address possible toxicity of nanomaterials as they interfere
with most in vitro screening tests based on colorimetric and fluorimetric probes such as the …

Nanomedicine has been considered a promising tool for biomedical research and clinical
practice in the 21st century because of the great impact nanomaterials could have on human …

The extensive use of rare earth elements (REEs) in a number of technologies is expected to
impact on human health, including occupational and environmental REE exposures. A body …

Iron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real
clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents …

Multifunctional nanoparticles combining therapy and imaging have the potential to improve
cancer treatment by allowing personalized therapy. Herein, we aimed to compare in vivo …

Although several nanomedicines got clinical approval over the past two decades, the clinical
translation rate is relatively small so far. There are many post-surveillance withdrawals of …

In the past decade, the study of extracellular vesicles (EVs), especially exosomes (50–150
nm) have attracted growing interest in numerous areas of cancer and tissue regeneration …