Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …

Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …

Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …

Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …

Brain, the major organ of the central nervous system controls and processes most of body
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …

The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Cancer cells display phenotypic equilibrium between the stem-like and differentiated states
during neoplastic homeostasis. The functional and mechanistic implications of this …