Scientific, sustainability and regulatory challenges of cultured meat

MJ Post, S Levenberg, DL Kaplan, N Genovese, J Fu… - Nature Food, 2020 - nature.com
Cellular agriculture is an emerging branch of biotechnology that aims to address issues
associated with the environmental impact, animal welfare and sustainability challenges of …

Role of immune cells in the removal of deleterious senescent cells

A Kale, A Sharma, A Stolzing, PY Desprez, J Campisi - Immunity & Ageing, 2020 - Springer
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a
complex senescence-associated secretory phenotype (SASP). The senescence arrest …

Cellular senescence: molecular targets, biomarkers, and senolytic drugs

N Kudlova, JB De Sanctis, M Hajduch - International Journal of Molecular …, 2022 - mdpi.com
Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …

Automation in the life science research laboratory

I Holland, JA Davies - Frontiers in bioengineering and biotechnology, 2020 - frontiersin.org
Protocols in the academic life science laboratory are heavily reliant on the manual
manipulation of tools, reagents and instruments by a host of research staff and students. In …

Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects

CY Ma, Y Zhai, CT Li, J Liu, X Xu… - Medicinal Research …, 2024 - Wiley Online Library
Mesenchymal stem cells (MSCs) are one of the few stem cell types used in clinical practice
as therapeutic agents for immunomodulation and ischemic tissue repair, due to their unique …

Mesenchymal stem cells as a cornerstone in a galaxy of intercellular signals: basis for a new era of medicine

S Fernández-Francos, N Eiro, LA Costa… - International journal of …, 2021 - mdpi.com
Around 40% of the population will suffer at some point in their life a disease involving tissue
loss or an inflammatory or autoimmune process that cannot be satisfactorily controlled with …

Aging and mesenchymal stem cells: basic concepts, challenges and strategies

M Fraile, N Eiro, LA Costa, A Martín, FJ Vizoso - Biology, 2022 - mdpi.com
Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

Automation fears: Drivers and solutions

S Ivanov, M Kuyumdzhiev, C Webster - Technology in Society, 2020 - Elsevier
New technologies offer employers the ability to replace tasks done by human labour with
those done by machines. There are challenges for both employers and employees, as …

Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers

AC Tsai, R Jeske, X Chen, X Yuan, Y Li - Frontiers in bioengineering …, 2020 - frontiersin.org
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …

Single-cell sorting based on secreted products for functionally defined cell therapies

H Miwa, R Dimatteo, J de Rutte, R Ghosh… - Microsystems & …, 2022 - nature.com
Cell therapies have emerged as a promising new class of “living” therapeutics over the last
decade and have been particularly successful for treating hematological malignancies …