Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …

Lungs undergo mechanical strain during breathing, but how these biophysical forces affect
cell fate and tissue homeostasis are unclear. We show that biophysical forces through …

Background Association of chromatin with lamin proteins at the nuclear periphery has
emerged as a potential mechanism to coordinate cell type-specific gene expression and …

Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …

Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at
the nuclear lamina (NL). A major question is how LAD–NL interactions are mediated and …

Alterations in nuclear shape are present in human diseases and ageing. A compromised
nuclear lamina is molecularly interlinked to altered chromatin functions and genomic …

The topological state of chromosomes determines their mechanical properties, dynamics,
and function. Recent work indicated that interphase chromosomes are largely free of …

In mammalian interphase nuclei, more than one thousand large genomic regions are
positioned at the nuclear lamina (NL). These lamina‐associated domains (LAD s) are …