4004 ESC Guidelines label use of medication should be limited to situations where it is in
the patient's interest to do so, with regard to the quality, safety, and efficacy of care, and only …

Purpose Genetic testing has advanced significantly since the publication of the 2011
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …

Purpose To characterize the genetic architecture of left ventricular noncompaction (LVNC)
and investigate the extent to which it may represent a distinct pathology or a secondary …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …

Heart contraction depends on a complicated array of interactions between sarcomeric
proteins required to convert chemical energy into mechanical force. Cyclic interactions …

Background Understanding the impact of gene interactions on disease phenotypes is
increasingly recognised as a crucial aspect of genetic disease research. This trend is …

Left ventricular non-compaction cardiomyopathy (LVNC) is a rare and unclassified
cardiomyopathy that carries the potential to cause heart failure, arrhythmias, and embolic …

STUDY QUESTION Could whole-exome sequencing (WES) be useful in clinical practice for
men with maturation arrest (MA) after a first testicular sperm extraction (TESE)? SUMMARY …

Noncompaction cardiomyopathy (NCCM) is a rare condition characterized by prominent
trabeculae, deep intertrabecular recesses, and a left ventricular myocardium with a two …

Objectives: Noncompaction Cardiomyopathy (NCCM) has been classified as primary
genetic cardiomyopathy and has gained increasing clinical awareness; however, little is …