Apolipoprotein C1: its pleiotropic effects in lipid metabolism and beyond
EV Fuior, AV Gafencu - International journal of molecular sciences, 2019 - mdpi.com
Apolipoprotein C1 (apoC1), the smallest of all apolipoproteins, participates in lipid transport
and metabolism. In humans, APOC1 gene is in linkage disequilibrium with APOE gene on …
and metabolism. In humans, APOC1 gene is in linkage disequilibrium with APOE gene on …
The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …
dependent gene-environment interactions that require analysis as a dynamic process in a …
The Alzheimer's disease exposome
CE Finch, AM Kulminski - Alzheimer's & Dementia, 2019 - Elsevier
Introduction Environmental factors are poorly understood in the etiology of Alzheimer's
disease (AD) and related dementias. The importance of environmental factors in gene …
disease (AD) and related dementias. The importance of environmental factors in gene …
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities
Background Alzheimer's disease (AD) is the most common cause of dementia in the elderly
and the sixth leading cause of death in the United States. AD is mainly considered a …
and the sixth leading cause of death in the United States. AD is mainly considered a …
Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk
AM Kulminski, I Philipp, L Shu, I Culminskaya - Neurobiology of aging, 2022 - Elsevier
Despite advances, the roles of genetic variants from the APOE-harboring 19q13. 32 region
in Alzheimer's disease (AD) remain controversial. We leverage a comprehensive approach …
in Alzheimer's disease (AD) remain controversial. We leverage a comprehensive approach …
Multi-modal imaging genetics data fusion by deep auto-encoder and self-representation network for Alzheimer's disease diagnosis and biomarkers extraction
Alzheimer's disease (AD) is an incurable neurodegenerative disease, so it is important to
intervene in the early stage of the disease. Brain imaging genetics is an effective technique …
intervene in the early stage of the disease. Brain imaging genetics is an effective technique …
The exposome in human evolution: from dust to diesel
BC Trumble, CE Finch - The Quarterly Review of Biology, 2019 - journals.uchicago.edu
Global exposures to air pollution and cigarette smoke are novel in human evolutionary
history and are associated with at least 12 million premature deaths per year. We investigate …
history and are associated with at least 12 million premature deaths per year. We investigate …
Prediction of Alzheimer's disease-associated genes by integration of GWAS summary data and expression data
Alzheimer's disease (AD) is the most common cause of dementia. It is the fifth leading cause
of death among elderly people. With high genetic heritability (79%), finding the disease's …
of death among elderly people. With high genetic heritability (79%), finding the disease's …
APOE region molecular signatures of Alzheimer's disease across races/ethnicities
The role of even the strongest genetic risk factor for Alzheimer's disease (AD), the
apolipoprotein E (APOE) ε4 allele, in its etiology remains poorly understood. We examined …
apolipoprotein E (APOE) ε4 allele, in its etiology remains poorly understood. We examined …
Genetic and regulatory architecture of Alzheimer's disease in the APOE region
Abstract Introduction Apolipoprotein E (APOE) ε2 and ε4 alleles encoded by rs7412 and
rs429358 polymorphisms, respectively, are landmark contra and pro “risk” factors for …
rs429358 polymorphisms, respectively, are landmark contra and pro “risk” factors for …