With the progress of the aging population, bone-related diseases such as osteoporosis and
osteoarthritis have become urgent problems. Recent studies have demonstrated the …

Osteoporosis is a type of bone loss disease characterized by a reduction in bone mass and
microarchitectural deterioration of bone tissue. With the intensification of global aging, this …

Estrogen increases bone formation by promoting mineralization and prolonging the lifespan
of osteoblasts. To understand the underlying molecular mechanism/s, we identified estrogen …

Objectives Oestrogen is known to inhibit osteoclastogenesis, and numerous studies have
identified it as an autophagic activator. To date, the role of oestrogen in the autophagy of …

Osteoclasts are the principal mediators of bone resorption. They form through the fusion of
mononuclear precursor cells under the principal influence of the cytokines macrophage …

Metastasis and recurrence are major causes of colorectal cancer (CRC) death, but their
molecular mechanisms are unclear. In this study, genes associated with CRC metastasis …

Shades of grey and brown are a dominant component in mammal coat colours, representing
a fundamental trait involved in a great number of processes including cryptism, sexual …

Inflammatory diseases have a negative impact on bone homeostasis via exacerbated local
and systemic inflammation. Bone resorbing osteoclasts are mainly derived from …

Estrogen (17β-estradiol) deficiency post-menopause alters bone homeostasis whereby
bone resorption by osteoclasts exceeds bone formation by osteoblasts, leading to …

Objective Long-term protective effects of menopausal hormone therapy (MHT) at fractures
with different doses and components are controversial. We analyzed the effect of MHT on …