Antiproteinases such as alpha‐2‐macroglobulin (A2M) play a role in hemostasis. A2M is
highly conserved throughout evolution and is a high molecular weight homo‐tetrameric …

Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …

Protein misfolding underlies the pathology of a large number of human disorders, many of
which are age-related. An exception to this is preeclampsia, a leading cause of pregnancy …

Abstract α2-Macroglobulin is a highly abundant serum protein involved in the development
of atherosclerosis and cardiac hypertrophy. However, its circulating molecular form and …

The brain-derived neurotrophic factor (BDNF) has been recently shown to have activating
effects in isolated platelets. However, BDNF circulates in plasma and a mechanism to …

Proteins represent extremely susceptible targets for oxidants. Oxidative modifications of
proteins may bring about violation of their structure and functionality. It implies that the …

Fibrinogen, a major constituent of blood plasma, is highly susceptible to reaction with
biological oxidants. It has been proposed that fibrinogen plays a role in antioxidant defence …

Human alpha-2-macroglobulin is a well-known inhibitor of a broad spectrum of proteases
and plays important roles in immunity, inflammation, and infections. Here, we report the cryo …

Luque et al. have described multiple structures of human alpha-2-macroglobulin (A2M)
determined from samples purified from frozen human plasma (1). The authors interpreted …

Human α2-macroglobulin (hα2M) is a large homotetrameric protein involved in the broad
inhibition of endopeptidases. Following cleavage within a bait region, hα2M undergoes …