Cancer cells can adapt to low energy sources in the face of ATP depletion as well as to their
high levels of ROS by altering their metabolism and energy production networks which might …

Angiogenesis is essential for tumor growth, metastasis, arteriosclerosis as well as embryonic
development and wound healing. Its process is dependent on cell proliferation, migration …

Multicellular organisms initiate adaptive responses when oxygen (O 2) availability
decreases, but the underlying mechanism of O 2 sensing remains elusive. We find that …

Objective—Reactive oxygen species have been implicated as signaling molecules
modulating the activity of redox-sensitive transcription factors such as nuclear factor kappa B …

Background—The cause of pulmonary arterial hypertension (PAH) was investigated in
humans and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain …

The hypoxia-inducible factor α-subunits (HIFα) are key transcription factors in the
mammalian response to oxygen deficiency. The HIFα regulation in response to hypoxia …

Angiogenesis, a process of new blood vessel formation, is a key process involved in normal
development and wound repair as well as in the various pathophysiologies such as …

Angiogenesis, a process of new blood vessel growth, contributes to various
pathophysiologies such as cancer, diabetic retinopathy and atherosclerosis. Accumulating …

In the last decade, it has become recognized that reactive oxygen species (ROS) play
important roles in the multiple biological processes involved in the pathophysiology of …

NADPH oxidases are important sources of reactive oxygen species (ROS), possibly
contributing to various disorders associated with enhanced proliferation. NOX4 appears to …