Advances in symptom management and in monitoring disease progression in motor neuron disease.

E Hobson, C McDermott - International Review of Neurobiology, 2024 - europepmc.org
The aim of supportive management of motor neuron disease is to improve survival, promote
good quality of life and patient independence and autonomy whilst preparing for future …

Cultivating Patient Preferences in ALS Clinical Trials: Reliability and Prognostic Value of the Patient-Ranked Order of Function

RPA van Eijk, LH van den Berg, Y Lu - Neurology, 2024 - AAN Enterprises
Background and Objectives The Patient-Ranked Order of Function (PROOF) is a novel
approach to account for patient-reported preferences in the evaluation of treatments of …

Comparison of in-person vs. remote administration of cognitive screening tools for people with ALS

L Didcote, S Vitoratou, A Al-Chalabi… - Neurological Sciences, 2024 - Springer
Objective This study investigated whether cognitive screening tools used for people with
amyotrophic lateral sclerosis (pwALS) are affected by the screen being administered face-to …

Listener effort quantifies clinically meaningful progression of dysarthria in people living with amyotrophic lateral sclerosis

I Navar Bingham, R Norel, EG Roitberg, J Peller… - medRxiv, 2024 - medrxiv.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative motor neuron disease that
causes progressive muscle weakness. Progressive bulbar dysfunction causes dysarthria …

Listener effort quantifies clinically meaningful progression of dysarthria in people living with amyotrophic lateral sclerosis

IN Bingham, R Norel, EG Roitberg, J Peller… - medRxiv, 2024 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative motor neuron disease that
causes progressive muscle weakness. Progressive bulbar dysfunction causes dysarthria …

Access for ALL in ALS: A large‐scale, inclusive, collaborative consortium to unlock the molecular and genetic mechanisms of amyotrophic lateral sclerosis

JD Berry, S Paganoni, MB Harms, N Shneider… - Muscle & … - Wiley Online Library
Recent progress in therapeutics for amyotrophic lateral sclerosis (ALS) has spurred
development and imbued the field of ALS with hope for more breakthroughs, yet substantial …