Great progress has been made over the past years in elucidating the structure and function
of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as …

Hepatitis C virus (HCV) causes acute and chronic liver disease in humans, including chronic
hepatitis, cirrhosis, and hepatocellular carcinoma. Studies of this virus have been hampered …

Many RNA viruses remodel intracellular membranes to generate specialized sites for RNA
replication. How membranes are remodeled and what properties make them conducive for …

The interferon-inducible transmembrane (IFITM) protein family represents a new class of
cellular restriction factors that block early stages of viral replication; the underlying …

Dengue virus is a worldwide-distributed mosquito-borne flavivirus with a positive strand
RNA genome. Its transcribed polyprotein is cleaved by host-and virus-encoded peptidases …

Flaviviruses are insect-borne, positive-strand RNA viruses that have been disseminated
worldwide. Their genome is translated into a polyprotein, which is subsequently cleaved by …

Plus-strand RNA virus replication occurs in tight association with cytoplasmic host cell
membranes. Both, viral and cellular factors cooperatively generate distinct organelle-like …

Like all other positive-strand RNA viruses, hepatitis C virus (HCV) induces rearrangements
of intracellular membranes that are thought to serve as a scaffold for the assembly of the …

Hepatitis C virus (HCV) infection is a global health concern affecting an estimated 3% of the
world's population. Recently, cell culture systems have been established, allowing …

Protein translocation into the endoplasmic reticulum (ER) is the first and decisive step in the
biogenesis of most extracellular and many soluble organelle proteins in eukaryotic cells. It is …