Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

Von Willebrand disease (VWD) is one of the most common inherited bleeding diseases.
Based on a conservative estimate of prevalence (at least 100 per million persons)(1-7) and …

von Willebrand disease (VWD) is a commonly encountered inherited bleeding disorder
affecting both males and females, causing mucous membrane and skin bleeding symptoms …

Von Willebrand's disease is an inherited bleeding disorder with a prevalence as high as 1 to
2 percent in the general population, according to screening studies. However, its prevalence …

Von Willebrand disease is a common autosomal inherited bleeding disorder caused by
quantitative or qualitative defects of von Willebrand factor, a multi-adhesive protein that …

In this study we have examined the mechanism of platelet aggregation under physiological
flow conditions using an in vitro flow-based platelet aggregation assay and an in vivo rat …

Platelet-adhesive mechanisms play a well-defined role in hemostasis and thrombosis, but
evidence continues to emerge for a relevant contribution to other pathophysiological …

Abstract von Willebrand factor (VWF) is a large multimeric adhesive glycoprotein with
complex roles in thrombosis and hemostasis. Abnormalities in VWF give rise to a variety of …

BACKGROUND: Von Willebrand's disease (VWD) is an autosomally inherited bleeding
disorder caused by a deficiency or abnormality of von Willebrand factor (VWF). VWF is a …

Background: von Willebrand factor (VWF) is a glycoprotein that plays an important role in
primary hemostasis. VWF is synthesized and stored in endothelial cells (ECs) and …