Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread
vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF …

Central nervous system diseases involving the parenchymal microvessels are frequently
associated with a 'microvasculopathy', which includes different levels of neurovascular unit …

Vascular endothelial barrier dysfunction underlies diseases such as acute respiratory
distress syndrome (ARDS), characterized by edema and inflammatory cell infiltration. The …

The role of Hedgehog (Hh) signaling in vascular biology has first been highlighted in
embryos by Pepicelli et al. in 1998 and Rowitch et al. in 1999. Since then, the proangiogenic …

Abstract Changes in the nerve's microenvironment and local inflammation resulting from
peripheral nerve injury participate in nerve sensitization and neuropathic pain development …

In the current work, we conducted an immunocytochemical search for markers of ongoing
neurogenesis (eg nestin) in auditory cortex from postmortem sections of autism spectrum …

Pericytes are functional components of the neurovascular unit (NVU) that are located around
the blood vessels, and their roles in the regulation of cerebral health and diseases has been …

Within the mandible, the odontogenic and osteogenic mesenchymes develop in a close
proximity and form at about the same time. They both originate from the cranial neural crest …

Consistent adult neurogenic activity in humans is observed in specific niches within the
central nervous system. However, the notion of an adult neurogenic niche is challenged by …

Hypoxia-inducible factor-1α (HIF-1α) involves in redox reactions. Considering the role of
reactive oxygen species (ROS) in platelet function, whether it regulates platelet function …