[HTML][HTML] Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance
S Vasseur, F Guillaumond - Oncogenesis, 2022 - nature.com
Lipids are essential constituents for malignant tumors, as they are absolutely required for
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …
The role of cholesterol in cancer
The roles played by cholesterol in cancer development and the potential of therapeutically
targeting cholesterol homeostasis is a controversial area in the cancer community. Several …
targeting cholesterol homeostasis is a controversial area in the cancer community. Several …
Acetyl-CoA metabolism supports multistep pancreatic tumorigenesis
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for
prevention and treatment are urgently needed. We previously reported that histone H4 …
prevention and treatment are urgently needed. We previously reported that histone H4 …
[HTML][HTML] Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the target of the statins, important
drugs that lower blood cholesterol levels and treat cardiovascular disease. Consequently …
drugs that lower blood cholesterol levels and treat cardiovascular disease. Consequently …
Cholesterol and cancer, in the balance
S Silvente-Poirot, M Poirot - Science, 2014 - science.org
Mammalian cells synthesize cholesterol through a series of 21 enzymatic steps, generating
numerous metabolites that are involved in the control of physiological and developmental …
numerous metabolites that are involved in the control of physiological and developmental …
[HTML][HTML] TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related
to tumor progression and therapy resistance across cancer types, including non-small cell …
to tumor progression and therapy resistance across cancer types, including non-small cell …
[HTML][HTML] Intracellular cholesterol synthesis and transport
Q Shi, J Chen, X Zou, X Tang - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular
disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in …
disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in …
[HTML][HTML] Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
Human epidermal growth factor receptor 2 (HER2) gene amplification and/or protein
overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although …
overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although …
[HTML][HTML] Enzymes in the cholesterol synthesis pathway: interactomics in the cancer context
P Ershov, L Kaluzhskiy, Y Mezentsev, E Yablokov… - Biomedicines, 2021 - mdpi.com
A global protein interactome ensures the maintenance of regulatory, signaling and structural
processes in cells, but at the same time, aberrations in the repertoire of protein–protein …
processes in cells, but at the same time, aberrations in the repertoire of protein–protein …
Molecular pathways: sterols and receptor signaling in cancer
L Gabitova, A Gorin, I Astsaturov - Clinical Cancer Research, 2014 - AACR
Accelerated cholesterol and lipid metabolism are the hallmarks of cancer and contribute to
malignant transformation due to the obligatory requirement for cholesterol for the function of …
malignant transformation due to the obligatory requirement for cholesterol for the function of …