Transcriptional regulatory networks (TRNs) play a crucial role in exploring microbial life
activities and complex regulatory mechanisms. The comprehensive reconstruction of TRNs …

Public gene expression databases are a rapidly expanding resource of organism responses
to diverse perturbations, presenting both an opportunity and a challenge for bioinformatics …

Abstract Group A Streptococcus (GAS) is a major human pathogen, causing diseases
ranging from mild superficial infections of the skin and pharyngeal epithelium to severe …

Streptococcus pyogenes is responsible for a range of diseases in humans contributing
significantly to morbidity and mortality. Among more than 200 serotypes of S. pyogenes …

Lactiplantibacillus plantarum is a probiotic bacterium widely used in food and health
industries, but its gene regulatory information is limited in existing databases, which …

Abstract iModulons—sets of co-expressed genes identified through independent component
analysis (ICA) of high-quality transcriptomic datasets—provide an unbiased, modular view of …

Streptococcus pyogenes is a human-specific pathogen that commonly colonizes the upper
respiratory tract and skin, causing a wide variety of diseases ranging from pharyngitis to …

As the availability of data sets increases, meta-analysis leveraging aggregated and
interoperable data types is proving valuable. This study leveraged a meta-analysis workflow …

There is growing interest in engineering Pseudomonas putida KT2440 as a microbial
chassis for the conversion of renewable and waste-based feedstocks, and metabolic …

Acinetobacter baumannii causes severe infections in humans, resists multiple antibiotics,
and survives in stressful environmental conditions due to modulations of its complex …