Although we have amassed extensive catalogues of signalling network components, our
understanding of the spatiotemporal control of emergent network structures has lagged …

Endocytosis has long been thought of as simply a way for cells to internalize nutrients and
membrane-associated molecules. But an explosive growth in knowledge has given a new …

Motile eukaryotic cells polarize in response to external signals. Numerous mechanisms
have been suggested to account for this symmetry breaking and for the ensuing robust …

Polarization, a primary step in the response of an individual eukaryotic cell to a spatial
stimulus, has attracted numerous theoretical treatments complementing experimental …

Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family,
play a vital role in the control of cell migration. Using predictive mathematical modeling …

Despite the large size of the Xenopus laevis egg (approximately 1.2 mm diameter), a
fertilized egg rapidly proceeds through mitosis in a spatially coordinated fashion. Mitosis is …

Toll-like receptors (TLRs) are the archetypal pattern recognition receptors in sensing
exogenous pathogens. Activation of TLRs is a first line of defense of the immune system …

A challenge in biology is to understand how complex molecular networks in the cell execute
sophisticated regulatory functions. Here we explore the idea that there are common and …

The advancements in “omics”(proteomics, genomics, lipidomics, and metabolomics)
technologies have yielded large inventories of genes, transcripts, proteins, and metabolites …

Individual cells within a population undergo apoptosis at distinct, apparently random time
points. By analyzing cellular mitotic history, we identified that sibling HeLa cell pairs, in …