A review on the role of cyclin dependent kinases in cancers
S Ghafouri-Fard, T Khoshbakht, BM Hussen… - Cancer Cell …, 2022 - Springer
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in
the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers …
the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers …
[HTML][HTML] Advances in cancer therapy: A comprehensive review of CDK and EGFR inhibitors
M Hawash - Cells, 2024 - mdpi.com
Protein kinases have essential responsibilities in controlling several cellular processes, and
their abnormal regulation is strongly related to the development of cancer. The …
their abnormal regulation is strongly related to the development of cancer. The …
Discovery of pyrazolo [3, 4-d] pyrimidine and pyrazolo [4, 3-e][1, 2, 4] triazolo [1, 5-c] pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and …
IF Nassar, MTA Aal, WA El-Sayed, MAE Shahin… - RSC …, 2022 - pubs.rsc.org
CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a
selective manner. A new set of small molecules featuring the privileged pyrazolo [3, 4-d] …
selective manner. A new set of small molecules featuring the privileged pyrazolo [3, 4-d] …
Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine …
AA Mandour, IF Nassar, MT Abdel Aal… - Journal of enzyme …, 2022 - Taylor & Francis
Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for
its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established …
its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established …
Indenyl-thiazole and indenyl-formazan derivatives: Synthesis, anticancer screening studies, molecular-docking, and pharmacokinetic/molin-spiration properties
GH Alfaifi, TA Farghaly, MH Abdellattif - Plos one, 2023 - journals.plos.org
Two new series of thiazole and formazan linked to 5-Bromo-indan were synthesized, and
their structures were assured based on all possible analytical techniques. The size of the …
their structures were assured based on all possible analytical techniques. The size of the …
[HTML][HTML] Synthesis, anticancer evaluation, and molecular modeling study of new 2-(phenylamino) pyrazolo [1, 5-a] pyrimidine analogues
OA Azher, A Hossan, RA Pashameah… - Arabian Journal of …, 2023 - Elsevier
Abstract The reaction of 3-amino-5-phenylaminopyrazoles 2 with 3-(dimethylamino)
acrylonitrile derivatives resulted in a series of substituted pyrazolopyrimidine analogues 4 …
acrylonitrile derivatives resulted in a series of substituted pyrazolopyrimidine analogues 4 …
BF3-Mediated Acetylation of Pyrazolo[1,5-a]pyrimidines and Other π-Excedent (N-Hetero)arenes
An operably simple microwave-assisted BF3-mediated acetylation reaction of pyrazolo [1, 5-
a] pyrimidines and a plausible mechanism based on density functional theory (DFT) …
a] pyrimidines and a plausible mechanism based on density functional theory (DFT) …
[HTML][HTML] Discovery of novel indene-based hybrids as breast cancer inhibitors targeting Hsp90: Synthesis, bio-evaluation and molecular docking study
AM Alosaimy, AS Abouzied, AMR Alsaedi… - Arabian Journal of …, 2023 - Elsevier
Inhibition of Heat-shock protein 90 (Hsp90) is considered an attractive route in fighting
against cancer proliferation. Herein, new indene derivatives targeting Hsp90 were …
against cancer proliferation. Herein, new indene derivatives targeting Hsp90 were …
Novel 6, 7, 8-trihydrobenzo [6', 7'] cyclohepta [2', 1'-e] pyrazolo [2, 3-a] pyrimidine derivatives as Topo IIα inhibitors with potential cytotoxic activity
TA Farghaly, HG Abdulwahab, HY Medrasi… - Bioorganic …, 2022 - Elsevier
Abstract Novel tetracyclic pyrazolo [1, 5-a] pyrimidine derivatives; namely benzo [3, 4]
cyclohepta [1, 2-e] pyrazolo [1, 5-a] pyrimidin-2-amines 6a-e and benzo [3, 4] cyclohepta [1 …
cyclohepta [1, 2-e] pyrazolo [1, 5-a] pyrimidin-2-amines 6a-e and benzo [3, 4] cyclohepta [1 …
Design, Synthesis, antimicrobial screening and molecular modeling of novel 6, 7 dimethylquinoxalin-2 (1H)-one and thiazole derivatives targeting DNA gyrase …
RM Alqurashi, TA Farghaly, R Sabour… - Bioorganic …, 2023 - Elsevier
Abstract New 6, 7-dimethylquinoxalin-2 (1H)-one and hydrazineylidene thiazol-4-one
derivatives were synthesized, and evaluated for their in vitro antimicrobial activity. The …
derivatives were synthesized, and evaluated for their in vitro antimicrobial activity. The …