Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the
most important. It is crucial to the very process that enables the chambers of the heart to …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Ca is critical in both the electrical and mechanical properties of cardiac myocytes, and much
is known about ionic currents and the normal excitation-contraction coupling process. In …

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We have developed a mathematical model of the mouse ventricular myocyte action potential
(AP) from voltage-clamp data of the underlying currents and Ca2+ transients. Wherever …