Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective

K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

The therapeutic potential of carbon monoxide

R Motterlini, LE Otterbein - Nature reviews Drug discovery, 2010 - nature.com
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic
molecule with important signalling capabilities in physiological and pathophysiological …

Developing drug molecules for therapy with carbon monoxide

CC Romao, WA Blättler, JD Seixas… - Chemical Society …, 2012 - pubs.rsc.org
The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …

Exploiting synergistic effect of CO/NO gases for soft tissue transplantation using a hydrogel patch

X Tang, J Ren, X Wei, T Wang, H Li, Y Sun… - Nature …, 2023 - nature.com
Autologous skin flap transplantation is a common method for repairing complex soft tissue
defects caused by cancer, trauma, and congenital malformations. Limited blood supply …

Adiponectin and cardiovascular health: an update

X Hui, KSL Lam, PM Vanhoutte… - British journal of …, 2012 - Wiley Online Library
The global epidemic of obesity is accompanied by an increased prevalence of
cardiovascular disease (CVD), in particular stroke and heart attack. Dysfunctional adipose …

Endothelial function

JA Vita - Circulation, 2011 - Am Heart Assoc
The endothelium regulates vascular tone, platelet activity, leukocyte adhesion, and
angiogenesis by producing nitric oxide and other regulatory factors. Risk factors decrease …

Emerging delivery strategies of carbon monoxide for therapeutic applications: from CO gas to CO releasing nanomaterials

H Yan, J Du, S Zhu, G Nie, H Zhang, Z Gu, Y Zhao - Small, 2019 - Wiley Online Library
Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of
gas therapy as it shows the promise of treating various diseases. Due to the gaseous …

CO-releasing molecules: a personal view

BE Mann - Organometallics, 2012 - ACS Publications
The development of CO-releasing molecules, CO-RMs, for medical applications is reviewed
from a personal point of view. The review covers the initial discovery of CO-RMs and then …

Carbon monoxide in lung cell physiology and disease

SW Ryter, KC Ma, AMK Choi - American Journal of …, 2018 - journals.physiology.org
Carbon monoxide (CO) is an endogenously produced gas that has gained recognition as a
biological signal transduction effector with properties similar, but not identical, to that of nitric …

Medical gas therapy for tissue, organ, and CNS protection: a systematic review of effects, mechanisms, and challenges

RD Zafonte, L Wang, CA Arbelaez… - Advanced …, 2022 - Wiley Online Library
Gaseous molecules have been increasingly explored for therapeutic development. Here,
following an analytical background introduction, a systematic review of medical gas …