Why does obesity cause diabetes?
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
[HTML][HTML] Mechanisms of insulin action and insulin resistance
MC Petersen, GI Shulman - Physiological reviews, 2018 - journals.physiology.org
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …
research into insulin action and resistance has issued. In the intervening century, some …
Triggering and resolution of inflammation in NASH
S Schuster, D Cabrera, M Arrese… - Nature reviews …, 2018 - nature.com
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …
Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases
VT Samuel, GI Shulman - Cell metabolism, 2018 - cell.com
NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …
Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
H Yki-Järvinen - The lancet Diabetes & endocrinology, 2014 - thelancet.com
Metabolic syndrome is a cluster of metabolic abnormalities that identifies people at risk of
diabetes and cardiovascular disease, whereas non-alcoholic fatty liver disease (NAFLD) is …
diabetes and cardiovascular disease, whereas non-alcoholic fatty liver disease (NAFLD) is …
Relationships between rodent white adipose fat pads and human white adipose fat depots
The objective of this review was to compare and contrast the physiological and metabolic
profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat …
profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat …
Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease
Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol
abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance …
abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance …
Mechanisms for insulin resistance: common threads and missing links
VT Samuel, GI Shulman - Cell, 2012 - cell.com
Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …
[HTML][HTML] Mechanisms and metabolic implications of regional differences among fat depots
T Tchkonia, T Thomou, YI Zhu, I Karagiannides… - Cell metabolism, 2013 - cell.com
Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex,
genetic background, disease state, certain drugs and hormones, development, and aging …
genetic background, disease state, certain drugs and hormones, development, and aging …