Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

L-5-hydroxytryptophan (5-HTP) is both a drug and a natural component of some dietary
supplements. 5-HTP is produced from tryptophan by tryptophan hydroxylase (TPH), which is …

Engineering cell metabolism for bioproduction not only consumes building blocks and
energy molecules (eg, ATP) but also triggers energetic inefficiency inside the cell. The …

Biomass-derived jet (bio-jet) fuel has become a key element in the aviation industry׳ s
strategy to reduce operating costs and environmental impacts. Researchers from the oil …

Microbial factories have been engineered to produce lipids from carbohydrate feedstocks for
production of biofuels and oleochemicals. However, even the best yields obtained to date …

Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

Harnessing lipogenic pathways and rewiring acyl-CoA and acyl-ACP (acyl carrier protein)
metabolism in Yarrowia lipolytica hold great potential for cost-efficient production of diesel …

The worldwide utilization of fossil energy, including its specific application as transportation
fuel, significantly contributes to the continuous increase of the atmospheric CO 2 …

Designing an optimal microbial cell factory often requires overexpression, knock-down, and
knock-out of multiple gene targets. Unfortunately, such rewiring of cellular metabolism is …

Sustainable production of oleochemicals requires establishment of cell factory platform
strains. The yeast Saccharomyces cerevisiae is an attractive cell factory as new strains can …