A systematic review of closed head injury models of mild traumatic brain injury in mice and rats

CN Bodnar, KN Roberts, EK Higgins… - Journal of …, 2019 - liebertpub.com
Mild TBI (mTBI) is a significant health concern. Animal models of mTBI are essential for
understanding mechanisms, and pathological outcomes, as well as to test therapeutic …

Beyond heat stress: intestinal integrity disruption and mechanism-based intervention strategies

P Lian, S Braber, J Garssen, HJ Wichers, G Folkerts… - Nutrients, 2020 - mdpi.com
The current climate changes have increased the prevalence and intensity of heat stress (HS)
conditions. One of the initial consequences of HS is the impairment of the intestinal epithelial …

Antioxidant therapies in traumatic brain injury

V Di Pietro, KM Yakoub, G Caruso, G Lazzarino… - Antioxidants, 2020 - mdpi.com
Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly
heterogeneous pathology, characterized by high mortality and disability rates. TBI is an …

Repetitive mild traumatic brain injury alters glymphatic clearance rates in limbic structures of adolescent female rats

J Christensen, DK Wright, GR Yamakawa, SR Shultz… - Scientific reports, 2020 - nature.com
The glymphatic system is the macroscopic waste clearance system for the central nervous
system. Glymphatic dysfunction has been linked to several neurological conditions …

Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities

B Hakiminia, B Alikiaii, F Khorvash… - Fundamental & …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is one of the most prevalent causes of permanent physical and
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …

Microglia dynamics in adolescent traumatic brain injury

E Eyolfson, A Khan, R Mychasiuk… - Journal of …, 2020 - Springer
Repetitive, mild traumatic brain injuries (RmTBIs) are increasingly common in adolescents
and encompass one of the largest neurological health concerns in the world. Adolescence is …

Potential biomarkers in Experimental Animal models for traumatic brain Injury

UM Deshetty, P Periyasamy - Journal of clinical medicine, 2023 - mdpi.com
Traumatic brain injury (TBI) is a complex and multifaceted disorder that has become a
significant public health concern worldwide due to its contribution to mortality and morbidity …

Clinical relevance of behavior testing in animal models of traumatic brain injury

SR Shultz, SJ McDonald, F Corrigan… - Journal of …, 2020 - liebertpub.com
Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often
suffering from consequences such as cognitive deficits, social abnormalities, anxiety …

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

K Socała, E Żmudzka, K Lustyk, M Zagaja… - Phytotherapy …, 2024 - Wiley Online Library
Neuropsychiatric disorders are anticipated to be a leading health concern in the near future,
emphasizing an outstanding need for the development of new effective therapeutics to treat …

Aquaporin 4 in traumatic brain injury: from molecular pathways to therapeutic target

E Dadgostar, S Rahimi, S Nikmanzar, S Nazemi… - Neurochemical …, 2022 - Springer
Traumatic brain injury (TBI) is known as an acute degenerative pathology of the central
nervous system, and has been shown to increase brain aquaporin 4 (AQP4) expression …