Recent advances in understanding the roles of immune checkpoints in allowing tumors to
circumvent the immune system have led to successful therapeutic strategies that have …

Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous
wheal development and/or angioedema for more than six weeks and at least twice a week …

Abstract Poliovirus receptor (PVR, CD155) has recently been gaining scientific interest as a
therapeutic target in the field of tumor immunology due to its prominent endogenous and …

CD226, a member of the immunoglobulin superfamily, is a functional protein initially
expressed on natural killer and T cells. In recent years, the function of CD226 has been …

Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds
of activation, these cells release a variety of preformed biologically active products, followed …

A large numbers of cell surface signaling molecules (CSSMs) have been molecularly
identified and functionally characterized in recent years and, via these studies, our …

Mast cells (MCs) are currently recognized as effector cells in many settings of the immune
response, including host defense, immune regulation, allergy, chronic inflammation, and …

White adipose tissue (WAT) is a heterogeneous tissue, found in various locations throughout
the body, containing mature adipocytes and the stroma-vascular fraction (SVF). The SVF …

An important role for natural killer (NK) cells in the regulation of T-cell responses is
emerging, although the receptor pairs regulating the NK–T-cell interaction have still not …

The allergic inflammatory response is composed of two main phases—the early and the late.
The early phase initiates when an allergen activates the tissue resident mast cell, triggering …