The epididymis is necessary for post-testicular sperm maturation as it provides the milieu
required for spermatozoa to gain the ability for progressive movement and fertilization. In the …

The disintegrin and metalloprotease domain-containing protein (ADAM) family of
multidomain membrane proteins comprises at least 34 members in mammals. More than …

If immunized with an antigen of interest, transgenic mice with large portions of unrearranged
human immunoglobulin loci can produce fully human antigen-specific antibodies; several …

A genetically modified mouse is provided, wherein the mouse is incapable of rearranging
and expressing an endogenous mouse immunoglobulin light chain variable sequence …

Research over the past 3 decades has caused a major shift in the way that the oviduct, or
fallopian tube, is perceived. Previously, it was regarded as little more than the anatomic site …

A crucial step of fertilization is the sperm-egg interaction that allows the two gametes to fuse
and create the zygote. In the mouse, CD9 on the egg and IZUMO1 on the sperm stand out as …

Eutherian spermatozoa are dependent on the environment of the proximal epididymis to
complete their maturation; however, no specific epididymal factors that mediate this process …

Spermatozoa are a focal point for the impact of sexual selection due to sperm competition
and sperm–female interactions in a wide range of sexually reproducing organisms. In-depth …

During spermatogenesis in mammalian testes, junction restructuring takes place at the
Sertoli–Sertoli and Sertoli–germ cell interface, which is coupled with germ cell development …

Mice are provided that comprise a reduction or deletion of ADAM6 activity from an
endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 …