DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in
Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional …

Metabolomics is the analysis of endogenous and exogenous low molecular mass
metabolites within a cell, tissue, or biofluid of an organism in response to an external …

The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes
mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear …

Background The small ruminant parasite Haemonchus contortus is the most widely used
parasitic nematode in drug discovery, vaccine development and anthelmintic resistance …

Cellular senescence can modulate various pathologies and is associated with irreparable
DNA double-strand breaks (IrrDSBs). Extracellular senescence metabolomes (ESMs) were …

Background Little is known about the role of amino acids in cellular signaling pathways,
especially as it pertains to pathways that regulate the rate of aging. However, it has been …

Malnutrition is common among older persons, with important consequences increasing
frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR …

Ageing has been defined as a global decline in physiological function depending on both
environmental and genetic factors. Here we identify gene transcripts that are similarly …

Metabolomics is the latest 'omics' technology and systems biology science that allows for
comprehensive profiling of small-molecule metabolites in biological systems at a specific …

Aging is an inevitable biochemical process that adversely affects personal health and poses
ever-increasing challenges to society. Recent research has revealed the crucial role of …