Fluorogenic probes, small-molecule sensors that unmask brilliant fluorescence upon
exposure to specific stimuli, are powerful tools for chemical biology. Those probes that …

The discovery of nalidixic acid is one pinnacle in medicinal chemistry, which opened a new
area of research that has led to the discovery of several life-saving antimicrobial agents …

The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …

Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of
tumors, which are an important cause of treatment resistance to conventional therapies …

Large tumours contain regions with very low intracellular O2 concentrations. Known as
hypoxia, this feature of tumours yields a highly reducing environment owing to the presence …

Gene-directed enzyme-prodrug therapy (GDEPT) is a promising anti-cancer strategy.
However, inadequate prodrugs, inefficient prodrug activation, and a lack of non-invasive …

Hypoxia is a prevalent feature of many tumors contributing to disease progression and
treatment resistance, and therefore constitutes an attractive therapeutic target. Several …

Activation of prodrugs in tumors (eg, by bioreduction in hypoxic zones) has the potential to
generate active metabolites that can diffuse within the tumor microenvironment. Such …

Nitroreductase (NTR) is overexpressed in hypoxic tumors. Moreover, hypoxia is usually
considered as the most important feature of various diseases. Thus, it is important to build a …

Triple-negative breast cancer (TNBC) is an aggressive malignancy with poor clinical
outcome and few validated drug targets. Two prevalent features of TNBC, tumor hypoxia and …