The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics
SA Kent, TL Spires-Jones, CS Durrant - Acta neuropathologica, 2020 - Springer
Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …
disease (AD) and, as such, have become the focus of therapeutic development. Recent …
Tau and tauopathies
T Arendt, JT Stieler, M Holzer - Brain research bulletin, 2016 - Elsevier
Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
Atypical, non-standard functions of the microtubule associated Tau protein
Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago,
most studies have focused on Tau's role in microtubule stability and regulation, as well as on …
most studies have focused on Tau's role in microtubule stability and regulation, as well as on …
Nuclear tau and its potential role in Alzheimer's disease
M Bukar Maina, YK Al-Hilaly, LC Serpell - Biomolecules, 2016 - mdpi.com
Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons
that constitutes one of the hallmarks of Alzheimer's disease (AD). For nearly four decades …
that constitutes one of the hallmarks of Alzheimer's disease (AD). For nearly four decades …
Association of micronucleus frequency with neurodegenerative diseases
Micronuclei (MNi) can originate either from chromosome breakage or chromosome
malsegregation events and are therefore ideal biomarkers to investigate genomic instability …
malsegregation events and are therefore ideal biomarkers to investigate genomic instability …
Chromosome instability, aging and brain diseases
Chromosome instability (CIN) has been repeatedly associated with aging and progeroid
phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic …
phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic …
Cell cycle activation and aneuploid neurons in Alzheimer's disease
T Arendt - Molecular neurobiology, 2012 - Springer
Alzheimer's disease (AD) is a chronic neurodegenerative disorder, characterized by
synaptic degeneration associated with fibrillar aggregates of the amyloid-ß peptide and the …
synaptic degeneration associated with fibrillar aggregates of the amyloid-ß peptide and the …
X chromosome aneuploidy in the Alzheimer's disease brain
YB Yurov, SG Vorsanova, T Liehr, AD Kolotii… - Molecular …, 2014 - Springer
Background Although the link between brain aging and Alzheimer's disease (AD) is a matter
of debate, processes hallmarking cellular and tissue senescence have been repeatedly …
of debate, processes hallmarking cellular and tissue senescence have been repeatedly …
[HTML][HTML] NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion
S Massone, E Ciarlo, S Vella, M Nizzari, T Florio… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Neuroblastoma Differentiation Marker 29 (NDM29) is a RNA polymerase (pol) III-transcribed
non-coding (nc) RNA whose synthesis drives neuroblastoma (NB) cell differentiation to a …
non-coding (nc) RNA whose synthesis drives neuroblastoma (NB) cell differentiation to a …
Stable inheritance of H3. 3-containing nucleosomes during mitotic cell divisions
Newly synthesized H3. 1 and H3. 3 histones are assembled into nucleosomes by different
histone chaperones in replication-coupled and replication-independent pathways …
histone chaperones in replication-coupled and replication-independent pathways …