Transferrin (Tf) is an essential protein, probably ubiquitous to all metazoans. The main
function of this family of proteins is to bind and transport ferric ions, increasing Fe (III) …

Iron acquisition is an essential aspect of cell physiology for most bacteria. Although much is
known about how bacteria initially recognize the various iron sources they can encounter …

The molecular evolution of the adaptive response at the host–pathogen interface has been
frequently referred to as an'arms race'between the host and bacterial pathogens. The innate …

Optimization of the systems for active-targeting drug delivery is a pending task in view of
more directed transport of the active components to neoplastic cells. One of the ways to …

Human serum transferrin binds ferric ions with high affinity and delivers them into cells via
receptor-mediated endocytosis upon a decrease in pH in the endosome. Protonation events …

Human serum transferrin (hTF) is an iron binding protein with the primary task of ensuring
well-controlled transport of Fe3+-ions in the bloodstream. Furthermore, hTF has been …

This study combines molecular dynamics (MD) simulations with small angle x-ray scattering
(SAXS) measurements to investigate the range of conformations that can be adopted by a …

The dynamical and thermodynamic behavior of human transferrin (hTf) protein in saline
aqueous solution of various concentrations is studied. hTf is an essential transport protein …

Fe (III) delivery from blood plasma to cells via the transferrin (Tf) cycle was studied
intensively due to its crucial role in Fe homeostasis. Tf-cycle disruptions are linked to …

Methods developed toward computational exploration of protein landscapes have become
standardized tools to assess biophysical experimental findings. They are also used on their …