Objective: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces
opioid system activation. The objective of this study was to determine whether opioid …

BackgroundRecent studies with intravenous (iv) application of ketamine show remarkable
but short-term success in patients with MDD. Studies in patients with chronic pain have used …

In vivo feasibility of using low-intensity focused ultrasound (FUS) to transiently modulate the
function of regional brain tissue has been recently tested in anesthetized lagomorphs [1] and …

Current antidepressants are ineffective in many depressed patients. Thus there is an urgent
need to develop treatment strategies which have significantly faster response, can be …

Detailed measurements of saccadic latency–the time taken to make an eye movement to a
suddenly-presented visual target–have proved a valuable source of detailed and …

Rationale Behavioural antidepressant-like effects of ketamine have been reported in the
forced swimming test (FST). The mechanisms mediating such effects are unknown …

Background: Ketamine, the NMDA glutamate receptor antagonist drug, is increasingly
employed as an experimental model of psychosis in healthy volunteers. At subanesthetic …

Background: Ketamine research in depression has mostly used intravenous, weight-based
approaches, which are difficult to translate clinically. Intranasal (IN) ketamine is a promising …

The pharmacological MRI (phMRI) technique is being increasingly used in both pre-clinical
and clinical models to investigate pharmacological effects on task-free brain function …

We present a dataset of eye-movement recordings collected from 60 participants, along with
their empathy levels, towards people with movement impairments. During each round of …