T-cell acute lymphoblastic leukemia (T-ALL) is biologically distinct from its B lymphoblastic
(B-ALL) counterpart and shows different kinetic patterns of disease response. Although very …

B-cell acute lymphoblastic lymphoma (B-ALL) is a disease found mainly in children and in
young adults. B-ALL is characterized by the rapid proliferation of poorly differentiated …

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed
whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep …

Background Type 2 innate lymphoid cells (ILC2s) represent an important type 2 immune
cell. Glucocorticoid regulation of human ILC2s is largely unknown. Objective We sought to …

A subset of B cell acute lymphoblastic leukemia (B-ALL) patients will relapse and succumb
to therapy-resistant disease. The bone marrow microenvironment may support B-ALL …

Human leukemias are liquid malignancies characterized by diffuse infiltration of the bone
marrow by transformed hematopoietic progenitors. The accessibility of tumor cells obtained …

Endogenous glucocorticoids (GCs) are steroid hormones that signal in virtually all cell types
to modulate tissue homeostasis throughout life. Also, synthetic GC derivatives …

Abstract (Patho-) physiological activation of the IL7-receptor (IL7R) signaling contributes to
steroid resistance in pediatric T-cell acute lymphoblastic leukemia (T-ALL). Here, we show …

Relapsed pediatric B-cell acute lymphoblastic leukemia (B-ALL) remains one of the leading
causes of cancer mortality in children. We performed Hi-C, ATAC-seq, and RNA-seq on 12 …

RAS pathway mutations have been linked to relapse and chemotherapy resistance in
pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However …