Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P Xie - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

[HTML][HTML] Brain–gut–microbiota axis in depression: A historical overview and future directions

L Chang, Y Wei, K Hashimoto - Brain Research Bulletin, 2022 - Elsevier
Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

Antidepressants can induce mutation and enhance persistence toward multiple antibiotics

Y Wang, Z Yu, P Ding, J Lu, L Mao… - Proceedings of the …, 2023 - National Acad Sciences
Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …

Gut microbial metabolites as multi-kingdom intermediates

KA Krautkramer, J Fan, F Bäckhed - Nature Reviews Microbiology, 2021 - nature.com
The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial

AC Schaub, E Schneider… - Translational …, 2022 - nature.com
A promising new treatment approach for major depressive disorder (MDD) targets the
microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions …

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation

X Wang, Z Wang, J Cao, Y Dong, Y Chen - Microbiome, 2023 - Springer
Background Sleep loss is a serious global health concern. Consequences include memory
deficits and gastrointestinal dysfunction. Our previous research showed that melatonin can …

[HTML][HTML] Role of microbiota-derived short-chain fatty acids in nervous system disorders

R Mirzaei, B Bouzari, SR Hosseini-Fard… - Biomedicine & …, 2021 - Elsevier
During the past decade, accumulating evidence from the research highlights the suggested
effects of bacterial communities of the human gut microbiota and their metabolites on health …

Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities

MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

The gut microbiome in depression and potential benefit of prebiotics, probiotics and synbiotics: a systematic review of clinical trials and observational studies

SR Alli, I Gorbovskaya, JCW Liu, NJ Kolla… - International journal of …, 2022 - mdpi.com
An emerging body of literature demonstrates differences in the gut microbiome (GMB) of
patients with major depressive disorder (MDD) compared to healthy controls (HC), as well …

The gut microbiome in social anxiety disorder: evidence of altered composition and function

MI Butler, TFS Bastiaanssen, C Long-Smith… - Translational …, 2023 - nature.com
The microbiome-gut-brain axis plays a role in anxiety, the stress response and social
development, and is of growing interest in neuropsychiatric conditions. The gut microbiota …