Gut microbiota and its metabolites in depression: from pathogenesis to treatment
L Liu, H Wang, X Chen, Y Zhang, H Zhang, P Xie - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …
Increasing preclinical and clinical studies have highlighted that compositional and functional …
[HTML][HTML] Brain–gut–microbiota axis in depression: A historical overview and future directions
Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …
worldwide. Despite abundant research, the precise mechanisms underlying the …
Antidepressants can induce mutation and enhance persistence toward multiple antibiotics
Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …
Gut microbial metabolites as multi-kingdom intermediates
KA Krautkramer, J Fan, F Bäckhed - Nature Reviews Microbiology, 2021 - nature.com
The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …
metabolites. These metabolites exert their effects within the host as signalling molecules and …
Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial
AC Schaub, E Schneider… - Translational …, 2022 - nature.com
A promising new treatment approach for major depressive disorder (MDD) targets the
microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions …
microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions …
Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation
X Wang, Z Wang, J Cao, Y Dong, Y Chen - Microbiome, 2023 - Springer
Background Sleep loss is a serious global health concern. Consequences include memory
deficits and gastrointestinal dysfunction. Our previous research showed that melatonin can …
deficits and gastrointestinal dysfunction. Our previous research showed that melatonin can …
[HTML][HTML] Role of microbiota-derived short-chain fatty acids in nervous system disorders
R Mirzaei, B Bouzari, SR Hosseini-Fard… - Biomedicine & …, 2021 - Elsevier
During the past decade, accumulating evidence from the research highlights the suggested
effects of bacterial communities of the human gut microbiota and their metabolites on health …
effects of bacterial communities of the human gut microbiota and their metabolites on health …
Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities
MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …
characterized by episodic and often progressive mood fluctuations with manic and …
The gut microbiome in depression and potential benefit of prebiotics, probiotics and synbiotics: a systematic review of clinical trials and observational studies
An emerging body of literature demonstrates differences in the gut microbiome (GMB) of
patients with major depressive disorder (MDD) compared to healthy controls (HC), as well …
patients with major depressive disorder (MDD) compared to healthy controls (HC), as well …
The gut microbiome in social anxiety disorder: evidence of altered composition and function
MI Butler, TFS Bastiaanssen, C Long-Smith… - Translational …, 2023 - nature.com
The microbiome-gut-brain axis plays a role in anxiety, the stress response and social
development, and is of growing interest in neuropsychiatric conditions. The gut microbiota …
development, and is of growing interest in neuropsychiatric conditions. The gut microbiota …