Epilepsy is one of the most common serious brain conditions, affecting over 70 million
people worldwide. Its incidence has a bimodal distribution with the highest risk in infants and …

Epileptic encephalopathies of infancy and childhood comprise a large, heterogeneous
group of severe epilepsies characterised by several seizure types, frequent epileptiform …

Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …

Understanding the aetiology of epilepsy is essential both for clinical management of patients
and for conducting neurobiological research that will direct future therapies. The aetiology of …

Epileptic seizures are widely regarded to occur as a result of the excitation-inhibition
imbalance from a neuro-centric view. Although astrocyte-neuron interactions are …

Genomics now has an increasingly important role in neurology clinics. Regarding the
epilepsies, innovations centred around technology, analytics, and collaboration have led to …

The persistence of intractable neurological disorders necessitates novel therapeutic
solutions. We demonstrate the utility of direct in situ electrophoretic drug delivery to treat …

Epilepsy is a complex neurological disorder affecting millions worldwide, with a substantial
number of patients facing drug-resistant epilepsy. This comprehensive review explores …

Figure 1. OEIP delivery of K+ directly to neural tissue to induce hyperexcitability a) Due to an
applied bias voltage, Vpump, cations are electrophoretically transported from the reservoir …

Temporal lobe epilepsy (TLE) is a common drug-resistant epilepsy associated with
abundant cell death in the hippocampus. Here, we develop a novel gene therapy-mediated …