CD8+ T cells are crucial to the control of Trypanosoma cruzi infection and probably act via
multiple mechanisms, the most important being the production of interferon‐γ (IFN‐γ). In the …

Chagas' disease, caused by Trypanosoma cruzi, has been considered a paradigm of
infection-induced autoimmune disease. Thus, the scarcity of parasites in the chronic phase …

The kinetics of effector CD8+-T-cell responses to specific Trypanosoma cruzi epitopes was
investigated after challenge. Our results suggest that the delayed kinetics differs from that …

The mechanism of cell death which occurs during Chagas' cardiopathy is disputed. To
address this issue we analyzed the molecular pathways implicated in the death of …

CTL and NK cells are critical for resistance to acute Trypanosoma cruzi infection, but are
also implicated in the pathology induced by this intracellular protozoan parasite. Here we …

Abstract Background Chronic Chagas disease presents different clinical manifestations
ranging from asymptomatic (namely indeterminate) to severe cardiac and/or digestive …

Cellular apoptosis induced by T cells is mainly mediated by two pathways. One, granule
exocytosis utilizes perforin/granzymes. The other involves signaling through death receptors …

Fas/Fas ligand (Fas-L) engagement, a potent inducer of apoptosis, is also important for
cellular activation, regulation of effector and chemotactic activity, and secretion of …

The haemoflagellate Trypanosoma cruzi is the causative agent of Chagas' disease that
occurs in approximately 8 million people in Latin America. Patients infected with T. cruzi …

Understanding the dual participation of the immune response in controlling the invader and
at the same time causing tissue damage might contribute to the design of effective new …