Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …

Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its
ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to …

Simple Summary Inflammation has been acknowledged as one of the causes of increased
cancer risk. Among the pro-inflammatory mediators, tumor necrosis factor alpha (TNFα) has …

Introduction: The Fas/FasL system plays a significant role in tumorigenesis. Research has
shown that its impairment in cancer cells may lead to apoptosis resistance and contribute to …

Cytokines have long been used for therapeutic applications in cancer patients. Substantial
side effects and unfavorable pharmacokinetics limit their application and may prevent dose …

Antibody-cytokine fusion proteins represent a novel class of biopharmaceuticals, with the
potential to increase the therapeutic index of cytokine 'payloads' and to promote leukocyte …

Tumor necrosis factor (TNF) plays a dual role in neurodegenerative diseases. Whereas TNF
receptor (TNFR) 1 is predominantly associated with neurodegeneration, TNFR2 is involved …

Cytokines are key players in stimulating and regulating immune responses in physiological
and pathophysiological processes. Various cytokines have been approved for therapy of …

The nonspecific interaction of proteins with surfaces in contact with biofluids leads to
adverse problems and is prevented by a biocompatible surface coating. The current …

Developing therapeutics that induce apoptosis in cancer cells has become an increasingly
attractive approach for the past 30 years. The discovery of tumor necrosis factor (TNF) …