Many short-lived and highly reactive oxygen species, such as superoxide anion (O2-) and
hydrogen peroxide (H2O2), are toxic or can create oxidative stress in cells, a response …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

It is now recognized that oxidative injury and mitochondrial dysfunction are responsible for
many clinical disorders with unmet needs, including ischemia–reperfusion injury …

Background Manifestations of reperfusion injury include myocyte death leading to infarction,
contractile dysfunction, and vascular injury characterized by the “no‐reflow” phenomenon …

Exercise provides protection against myocardial ischemia-reperfusion (IR) injury.
Understanding the mechanisms of this protection may lead to new interventions for the …

Patients with diabetes are more vulnerable to myocardial ischemia/reperfusion (MI/R) injury,
which is associated with excessive reactive oxygen species (ROS) generation and …

The ability of exercise to protect the heart against ischemia-reperfusion (I/R) injury is well
known in both human epidemiological studies and experimental animal models. In this …

In view of the critical role of redox system in numerous physiological and pathophysiological
processes, it is important to clearly understand the family members and regulatory …

We recently showed that Bendavia, a novel mitochondria-targeting peptide, reduced
infarction and no-reflow across several experimental models. The purpose of this study was …

Carthamus tinctorius L.(safflower) is one of the most commonly used Chinese herbal
medicines to prevent and treat cardiac disease in clinical practice. However, the …