The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Rab molecular switches are key players in defining membrane identity and regulating
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …

Epithelial-to-mesenchymal transition (EMT) underlies immunosuppression, drug resistance,
and metastasis in epithelial malignancies. However, the way in which EMT orchestrates …

Transport of different intracellular cargoes along cytoskeleton filaments is essential for the
morphogenesis and function of a broad variety of eukaryotic cells. Intracellular transport is …

G protein–coupled receptors (GPCRs) contribute to the regulation of every aspect of human
physiology and are therapeutic targets for the treatment of numerous diseases. As a …

The mevalonate pathway is a crucial metabolic pathway for most eukaryotic cells.
Cholesterol is a highly recognized product of this pathway but growing interest is being …

Spinal muscular atrophy is a disorder of lower motor neurons, most commonly caused by
recessive mutations in SMN1 on chromosome 5q. Cases without SMN1 mutations are …

Cytoplasmic dynein is the major minus end-directed microtubule motor in eukaryotes.
However, there is little structural insight into how different cargos are recognized and linked …

Protein biochips are of high interest for various fields of biotechnology, such as bioanalytics,
proteomics, biocatalysis, and biomaterials.[1–8] For protein-biochip preparation, the oriented …