Protein misfolding and amyloid nucleation through liquid–liquid phase separation
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
From Fundamental Amyloid Protein Self-Assembly to Development of Bioplastics
Proteins can self-assemble into a range of nanostructures as a result of molecular
interactions. Amyloid nanofibrils, as one of them, were first discovered with regard to the …
interactions. Amyloid nanofibrils, as one of them, were first discovered with regard to the …
Single-molecule FRET unmasks structural subpopulations and crucial molecular events during FUS low-complexity domain phase separation
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates
Biomolecular condensates are viscoelastic materials. Here we investigate the determinants
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
Local environment in biomolecular condensates modulates enzymatic activity across length scales
M Gil-Garcia, AI Benítez-Mateos, M Papp… - Nature …, 2024 - nature.com
The mechanisms that underlie the regulation of enzymatic reactions by biomolecular
condensates and how they scale with compartment size remain poorly understood. Here we …
condensates and how they scale with compartment size remain poorly understood. Here we …
Multidimensional super-resolution microscopy unveils nanoscale surface aggregates in the aging of FUS condensates
The intracellular liquid–liquid phase separation (LLPS) of biomolecules gives rise to
condensates that act as membrane-less organelles with vital functions. FUS, an RNA …
condensates that act as membrane-less organelles with vital functions. FUS, an RNA …
Controlling Drug Partitioning in Individual Protein Condensates through Laser-Induced Microscale Phase Transitions
A Leppert, J Feng, V Railaite… - Journal of the …, 2024 - ACS Publications
Gelation of protein condensates formed by liquid–liquid phase separation occurs in a wide
range of biological contexts, from the assembly of biomaterials to the formation of fibrillar …
range of biological contexts, from the assembly of biomaterials to the formation of fibrillar …
Spontaneous Transition of Spherical Coacervate to Vesicle‐Like Compartment
Numerous biological systems contain vesicle‐like biomolecular compartments without
membranes, which contribute to diverse functions including gene regulation, stress …
membranes, which contribute to diverse functions including gene regulation, stress …
Dipping contacts–a novel type of contact site at the interface between membraneless organelles and membranes
C Hoffmann, D Milovanovic - Journal of cell science, 2023 - journals.biologists.com
Liquid–liquid phase separation is a major mechanism for organizing macromolecules,
particularly proteins with intrinsically disordered regions, in compartments not limited by a …
particularly proteins with intrinsically disordered regions, in compartments not limited by a …
Adding intrinsically disordered proteins to biological ageing clocks
D Dormann, EA Lemke - Nature Cell Biology, 2024 - nature.com
Research into how the young and old differ, and which biomarkers reflect the diverse
biological processes underlying ageing, is a current and fast-growing field. Biological clocks …
biological processes underlying ageing, is a current and fast-growing field. Biological clocks …