Ubiquitylation is a critical post-translational modification that controls a wide variety of
processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different …

The HECT E3 ligase family regulates key cellular signaling pathways, with its 28 members
divided into three subfamilies: NEDD4 subfamily (9 members), HERC subfamily (6 …

The human UBR5 is a single polypeptide chain homology to E6AP C terminus (HECT)-type
E3 ubiquitin ligase essential for embryonic development in mammals. Dysregulated UBR5 …

The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also
incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of …

HACE1 is an ankyrin repeat (AKR) containing HECT‐type E3 ubiquitin ligase that interacts
with and ubiquitinates multiple substrates. While HACE1 is a well‐known tumor suppressor …

The HECT family of E3 ubiquitin ligase is divided into three subfamilies: the NEDD4, the
HERC, and the 'other'. Previous studies have mostly targeted members of the NEDD4 …

Abstract Domains found in ubiquitin specific proteases (DUSPs) occur in seven members of
the ubiquitin specific protease (USP) family. DUSPs are defined by a distinct structural fold …

Ubiquitinases are known to catalyze ubiquitin chains on target proteins to regulate various
physiological functions like cell proliferation, autophagy, apoptosis, and cell cycle …

There are 28 unique human members of the homologous to E6AP C-terminus (HECT) E3
ubiquitin ligase family. Each member of the HECT E3 ubiquitin ligases contains a conserved …

Phosphorylation-dependent binding of the S. cerevisiae Spt6p tSH2 domain (Spt6ptSH2) to
the Rbp1p subunit of RNA polymerase II supports efficient transcription. Here, we report that …