[HTML][HTML] Emerging functions of branched ubiquitin chains
ME French, CF Koehler, T Hunter - Cell discovery, 2021 - nature.com
Ubiquitylation is a critical post-translational modification that controls a wide variety of
processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different …
processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different …
Exploring the “Other” subfamily of HECT E3-ligases for therapeutic intervention
S Singh, J Ng, J Sivaraman - Pharmacology & Therapeutics, 2021 - Elsevier
The HECT E3 ligase family regulates key cellular signaling pathways, with its 28 members
divided into three subfamilies: NEDD4 subfamily (9 members), HERC subfamily (6 …
divided into three subfamilies: NEDD4 subfamily (9 members), HERC subfamily (6 …
Structure of the human UBR5 E3 ubiquitin ligase
The human UBR5 is a single polypeptide chain homology to E6AP C terminus (HECT)-type
E3 ubiquitin ligase essential for embryonic development in mammals. Dysregulated UBR5 …
E3 ubiquitin ligase essential for embryonic development in mammals. Dysregulated UBR5 …
[HTML][HTML] IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation
V Mishra, A Crespo-Puig, C McCarthy… - Nature …, 2023 - nature.com
The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also
incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of …
incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of …
Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization
S Singh, S Machida, NK Tulsian, YK Choong… - Advanced …, 2023 - Wiley Online Library
HACE1 is an ankyrin repeat (AKR) containing HECT‐type E3 ubiquitin ligase that interacts
with and ubiquitinates multiple substrates. While HACE1 is a well‐known tumor suppressor …
with and ubiquitinates multiple substrates. While HACE1 is a well‐known tumor suppressor …
Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity
S Singh, J Sivaraman - Biochemical Journal, 2020 - portlandpress.com
The HECT family of E3 ubiquitin ligase is divided into three subfamilies: the NEDD4, the
HERC, and the 'other'. Previous studies have mostly targeted members of the NEDD4 …
HERC, and the 'other'. Previous studies have mostly targeted members of the NEDD4 …
A panel of engineered ubiquitin variants targeting the family of domains found in ubiquitin specific proteases (DUSPs)
Abstract Domains found in ubiquitin specific proteases (DUSPs) occur in seven members of
the ubiquitin specific protease (USP) family. DUSPs are defined by a distinct structural fold …
the ubiquitin specific protease (USP) family. DUSPs are defined by a distinct structural fold …
A review: targeting UBR5 domains to mediate emerging roles and mechanisms: chance or necessity?
Y Wang, K Niu, Y Shi, F Zhou, X Li, Y Li… - … Journal of Surgery, 2024 - journals.lww.com
Ubiquitinases are known to catalyze ubiquitin chains on target proteins to regulate various
physiological functions like cell proliferation, autophagy, apoptosis, and cell cycle …
physiological functions like cell proliferation, autophagy, apoptosis, and cell cycle …
Redefining the catalytic HECT domain boundaries for the HECT E3 ubiquitin ligase family
EI Kane, SA Beasley, JM Schafer, JE Bohl… - Bioscience …, 2022 - portlandpress.com
There are 28 unique human members of the homologous to E6AP C-terminus (HECT) E3
ubiquitin ligase family. Each member of the HECT E3 ubiquitin ligases contains a conserved …
ubiquitin ligase family. Each member of the HECT E3 ubiquitin ligases contains a conserved …
Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters
J Madrigal, HL Schubert, MA Sdano, L McCullough… - bioRxiv, 2024 - biorxiv.org
Phosphorylation-dependent binding of the S. cerevisiae Spt6p tSH2 domain (Spt6ptSH2) to
the Rbp1p subunit of RNA polymerase II supports efficient transcription. Here, we report that …
the Rbp1p subunit of RNA polymerase II supports efficient transcription. Here, we report that …