Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

The activation strain or distortion/interaction model is a tool to analyze activation barriers that
determine reaction rates. For bimolecular reactions, the activation energies are the sum of …

Conspectus Bridged and fused rings are commonly found in biologically important
molecules. Current tactics to construct these ring systems are primarily based on stepwise …

1. INTRODUCTION Within 14 years of the seminal experiments of JD Roberts leading to the
first proposal of the structure of benzyne (1), 1 synthetic organic chemists recognized the …

This Minireview highlights recent advances in the field of aryne and cyclohexyne chemistry
that have allowed the extraordinary reactivity of these entities to be harnessed during the …

The distortion/interaction model has been used to explain and predict reactivity in a variety
of reactions where more common explanations, such as steric and electronic factors, do not …

This review describes our laboratory's efforts to develop transition metal-catalyzed cross-
couplings of several unconventional phenol-based electrophiles. Specifically, we highlight …

Heterocyclic arynes, or hetarynes, have been studied for over 100 years. However,
challenges associated with observing these reactive species, as well as developing …

Recent developments in aryne chemistry are reviewed with a particular focus on synthetic
methods. This includes an overview of the precursors of arynes and their activators; the …

C4-decorated indoles feature in a plethora of bioactive and functional compounds of
importance to natural product synthesis, material sciences, as well as crop protection and …