Chronic inflammation is a highly prevalent consequence of changes in environmental and
lifestyle factors that contribute to the development of cancer. The basis for this critical …

Transforming growth factor β (TGFβ) is implicated in human malignancy. Tumors may
escape the tumor suppressor activity of TGFβ by mutating some of its signaling components …

Epithelial-mesenchymal (EMT) and mesenchymal-epithelial (MET) transitions occur in the
development of human tumorigenesis and are part of the natural history of the process to …

Different molecular subtypes of glioblastoma (GBM) have been recently identified, of which
the mesenchymal subtype is associated with worst prognoses. Here, we report that …

Abstract MTA1, SOX4, EZH2, and TGF-β are all potent inducers of epithelial–mesenchymal
transition (EMT) in cancer; however, the signaling relationship among these molecules in …

Abstract Lysine-specific demethylase 1 (LSD1), which has been considered as a potential
therapeutic target in human cancer, has been known to regulate many biological functions …

Cancer cells are remarkably adaptive to diverse survival strategies, probably due to its
ability to interpret signaling cues differently than the normal cells. It appears as if cancer cells …

Programmed death‐ligand 1 (PD‐L1) plays a crucial role in the host immune system in
cancer progression. The gene promoter region of PD‐L1 also contains a binding site for ZEB …

Glioblastoma (GBM) is the most common and malignant intracranial tumor in adults. Despite
continuous improvements in diagnosis and therapeutic method, the prognosis is still far …

Cancer cells frequently exhibit deregulation of coregulatory molecules to drive the process
of growth and metastasis. One such group of ubiquitously expressed coregulators is the …