For therapeutic materials to be successfully delivered to the heart, several barriers need to
be overcome, including the anatomical challenges of access, the mechanical force of the …

In the past decades, numerous preclinical studies and several clinical trials have evidenced
the feasibility of cell transplantation in treating heart diseases. Over the years, different …

Cardiac patches are an effective way to deliver therapeutics to the heart. However, such
procedures are normally invasive and difficult to perform. Here, we develop and test a …

Stem cell-based therapies are steadily gaining traction for regenerative medicine
approaches to treating disease and injury throughout the body. While a significant body of …

Transplantation of stem cells into the heart can improve cardiac function after myocardial
infarction and in chronic heart failure, but the extent of benefit and of reproducibility of this …

Novel bio-therapeutic agents that harness the properties of small, non-coding nucleic acids
hold great promise for clinical applications. These include antisense oligonucleotides that …

Recently, injectable biomaterial-based therapies for cardiovascular disease have been
gaining attention, because they have shown therapeutic potential in preclinical models for …

Congestive heart failure accounts for half a million deaths per year in the United States.
Despite its place among the leading causes of morbidity, pharmacological and mechanic …

Advances in understanding the molecular basis of myocardial dysfunction, together with the
evolution of increasingly efficient gene transfer technology, make gene-based therapy a …

Although cell therapy has shown potential efficacy in the treatment of heart diseases, one
challenge is low cellular retention rate and poor engraftment. We sought to perform a head …