[HTML][HTML] Praziquantel use in aquaculture–Current status and emerging issues
Parasitic diseases are major constraints in fish mariculture. The anthelmintic praziquantel
(PZQ) can effectively treat a range of flatworm parasites in a variety of fish species and has …
(PZQ) can effectively treat a range of flatworm parasites in a variety of fish species and has …
Perspective on schistosomiasis drug discovery: highlights from a schistosomiasis drug discovery workshop at Wellcome Collection, London, September 2022
N Caldwell, R Afshar, B Baragaña… - ACS infectious …, 2023 - ACS Publications
In September 2022, the Drug Discovery Unit at the University of Dundee, UK, organised an
international meeting at the Wellcome Collection in London to explore the current clinical …
international meeting at the Wellcome Collection in London to explore the current clinical …
Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity
CM Rohr, DJ Sprague, SK Park… - Proceedings of the …, 2023 - National Acad Sciences
The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other
infections caused by parasitic flatworms. A schistosome target for PZQ was recently …
infections caused by parasitic flatworms. A schistosome target for PZQ was recently …
[HTML][HTML] Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
Control and elimination of the parasitic disease schistosomiasis relies on mass
administration of praziquantel. Whilst these programmes reduce infection prevalence and …
administration of praziquantel. Whilst these programmes reduce infection prevalence and …
Praziquantel: An update on the mechanism of its action against schistosomiasis and new therapeutic perspectives
RA Nogueira, MGS Lira, ICL Licá, GCCG Frazão… - Molecular and …, 2022 - Elsevier
Praziquantel (PZQ) is the drug of choice for the treatment of all forms of schistosomiasis,
although its mechanisms of action are not completely understood. PZQ acts largely on adult …
although its mechanisms of action are not completely understood. PZQ acts largely on adult …
Target-based discovery of a broad-spectrum flukicide
DJ Sprague, SK Park, S Gramberg, L Bauer… - Nature Structural & …, 2024 - nature.com
Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide.
Many of these diseases—for example, the parasitic blood fluke infection schistosomiasis …
Many of these diseases—for example, the parasitic blood fluke infection schistosomiasis …
Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel
W Le Clec'h, FD Chevalier, ACA Mattos… - Science translational …, 2021 - science.org
Mass drug administration with praziquantel (PZQ) monotherapy is considered the mainstay
for control and elimination of the parasites causing schistosomiasis in humans. This drug …
for control and elimination of the parasites causing schistosomiasis in humans. This drug …
Advances in new target molecules against schistosomiasis: A comprehensive discussion of physiological structure and nutrient intake
Schistosomiasis, a severe parasitic disease, is primarily caused by Schistosoma mansoni,
Schistosoma japonicum, or Schistosoma haematobium. Currently, praziquantel is the only …
Schistosoma japonicum, or Schistosoma haematobium. Currently, praziquantel is the only …
Disulfiram and dithiocarbamate analogues demonstrate promising antischistosomal effects
GA Rennar, TL Gallinger, P Mäder… - European Journal of …, 2022 - Elsevier
Schistosomiasis is a neglected tropical disease with more than 200 million new infections
per year. It is caused by parasites of the genus Schistosoma and can lead to death if left …
per year. It is caused by parasites of the genus Schistosoma and can lead to death if left …
A review of the genetic determinants of praziquantel resistance in Schistosoma mansoni: Is praziquantel and intestinal schistosomiasis a perfect match?
S Summers, T Bhattacharyya, F Allan… - Frontiers in Tropical …, 2022 - frontiersin.org
Schistosomiasis is a neglected tropical disease (NTD) caused by parasitic trematodes
belonging to the Schistosoma genus. The mainstay of schistosomiasis control is the delivery …
belonging to the Schistosoma genus. The mainstay of schistosomiasis control is the delivery …