[HTML][HTML] Praziquantel use in aquaculture–Current status and emerging issues

LJ Norbury, S Shirakashi, C Power, BF Nowak… - International Journal for …, 2022 - Elsevier
Parasitic diseases are major constraints in fish mariculture. The anthelmintic praziquantel
(PZQ) can effectively treat a range of flatworm parasites in a variety of fish species and has …

Perspective on schistosomiasis drug discovery: highlights from a schistosomiasis drug discovery workshop at Wellcome Collection, London, September 2022

N Caldwell, R Afshar, B Baragaña… - ACS infectious …, 2023 - ACS Publications
In September 2022, the Drug Discovery Unit at the University of Dundee, UK, organised an
international meeting at the Wellcome Collection in London to explore the current clinical …

Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity

CM Rohr, DJ Sprague, SK Park… - Proceedings of the …, 2023 - National Acad Sciences
The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other
infections caused by parasitic flatworms. A schistosome target for PZQ was recently …

[HTML][HTML] Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration

DJ Berger, T Crellen, PHL Lamberton, F Allan… - Nature …, 2021 - nature.com
Control and elimination of the parasitic disease schistosomiasis relies on mass
administration of praziquantel. Whilst these programmes reduce infection prevalence and …

Praziquantel: An update on the mechanism of its action against schistosomiasis and new therapeutic perspectives

RA Nogueira, MGS Lira, ICL Licá, GCCG Frazão… - Molecular and …, 2022 - Elsevier
Praziquantel (PZQ) is the drug of choice for the treatment of all forms of schistosomiasis,
although its mechanisms of action are not completely understood. PZQ acts largely on adult …

Target-based discovery of a broad-spectrum flukicide

DJ Sprague, SK Park, S Gramberg, L Bauer… - Nature Structural & …, 2024 - nature.com
Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide.
Many of these diseases—for example, the parasitic blood fluke infection schistosomiasis …

Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel

W Le Clec'h, FD Chevalier, ACA Mattos… - Science translational …, 2021 - science.org
Mass drug administration with praziquantel (PZQ) monotherapy is considered the mainstay
for control and elimination of the parasites causing schistosomiasis in humans. This drug …

Advances in new target molecules against schistosomiasis: A comprehensive discussion of physiological structure and nutrient intake

P Zhu, K Wu, C Zhang, SS Batool, A Li, Z Yu… - PLoS …, 2023 - journals.plos.org
Schistosomiasis, a severe parasitic disease, is primarily caused by Schistosoma mansoni,
Schistosoma japonicum, or Schistosoma haematobium. Currently, praziquantel is the only …

Disulfiram and dithiocarbamate analogues demonstrate promising antischistosomal effects

GA Rennar, TL Gallinger, P Mäder… - European Journal of …, 2022 - Elsevier
Schistosomiasis is a neglected tropical disease with more than 200 million new infections
per year. It is caused by parasites of the genus Schistosoma and can lead to death if left …

A review of the genetic determinants of praziquantel resistance in Schistosoma mansoni: Is praziquantel and intestinal schistosomiasis a perfect match?

S Summers, T Bhattacharyya, F Allan… - Frontiers in Tropical …, 2022 - frontiersin.org
Schistosomiasis is a neglected tropical disease (NTD) caused by parasitic trematodes
belonging to the Schistosoma genus. The mainstay of schistosomiasis control is the delivery …