Modern instrumentation for calorimetry permits direct determination of enthalpy values for
binding reactions and conformational transitions in biomolecules. Complete thermodynamic …

Since the discovery of the DNA intercalation process by Lerman in 1961 thousands of
organic, inorganic octahedral (particularly ruthenium (II) and rhodium (III)) and square …

A number of small molecules bind directly and selectively to DNA, acting as
chemotherapeutic agents by inhibiting replication, transcription or topoisomerase activity …

The equilibrium binding of the cytotoxic plant alkaloid berberine to various DNAs and
energetics of the interaction have been studied. At low ratios of bound alkaloid to base pair …

Anthracyclines have received significant attention due to their effectiveness and extensive
use as anticancer agents. At present, the clinical use of these drugs is offset by drug …

According to a widespread model, anti-cancer chemotherapy involves the triggering of tumor
cells to undergo apoptosis, so apoptosis-resistant cells would be recalcitrant to such …

Failure to eliminate cancer cells that have been exposed to cytotoxic agents may contribute
to the development of resistance to antitumor drugs. A widespread model in present day …

The anthracycline antibiotics daunorubicin and doxorubicin have been used widely as
anticancer drugs, but their cardiotoxicity limits their clinical use. We describe here the …

We describe the synthesis and characterization of a novel bioconjugate, consisting of an
octaarginine cell-penetrating peptide and a highly DNA-affine doxorubicin dimer. The …

DNA-binding compounds are of extraordinary importance in medicine, accounting for a
substantial portion of antitumor drugs in clinical usage. However, their mechanisms of action …