The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

Massively parallel DNA-sequencing systems provide sequence of huge numbers of different
DNA strands at once. These technologies are revolutionizing our understanding in medical …

Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell responses and direct their differentiation into effector …

Single-cell RNA-seq has emerged as a powerful tool in diverse applications, from
determining the cell-type composition of tissues to uncovering regulators of developmental …

The GENCODE Consortium aims to identify all gene features in the human genome using a
combination of computational analysis, manual annotation, and experimental validation …

Abstract PhosphoSitePlus (http://www. phosphosite. org) is an open, comprehensive,
manually curated and interactive resource for studying experimentally observed post …

Abstract The National Center for Biotechnology Information (NCBI) Reference Sequence
(RefSeq) database is a collection of genomic, transcript and protein sequence records …

Prior biological knowledge and phenotype information may help to identify disease genes
from human whole-genome and whole-exome sequencing studies. We developed …

Abstract The UniProt Knowledgebase (UniProtKB) acts as a central hub of protein
knowledge by providing a unified view of protein sequence and functional information …

We present a systematic review of pleiotropy among SNPs and genes reported to show
genome-wide association with common complex diseases and traits. We find abundant …