The recently uncovered key role of the peripheral and central nervous systems in controlling
tumorigenesis and metastasis has opened a new area of research to identify innovative …

Traditionally, γ-aminobutyric acid (GABA) is best known for its role as a primary inhibitory
neurotransmitter reducing neuronal excitability in the mammalian central nervous system …

Although nanoplastics (NPs) can penetrate the blood–brain barrier and accumulate in the
brain, the neurotoxicity of these particles and the mechanisms associated with their unique …

The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and
proliferation within the leptomeninges (LM) are poorly understood, which limits the …

Cancer cells possess various biological processes to ensure survival and proliferation even
under unfavorable conditions such as hypoxia, nutrient deprivation, and oxidative stress …

Medulloblastoma is a highly malignant pediatric brain tumor characterized by its aggressive
nature and limited treatment options. Metabolic changes have recently emerged as key …

Abstract PI3K/AKT/mTOR signalling contributes to several cardiovascular disorders. The aim
of this study was to examine the PI3K/AKT/mTOR pathway in myxomatous mitral valve …

Tumor-specific alterations in metabolism have been recognized to sustain the production of
ATP and macromolecules needed for cell growth, division and survival in many cancer …

Simple Summary The current treatment options for medulloblastoma, the most common
malignant childhood brain cancer, are associated with many negative side effects and …

Studies suggest that the expression of glutamate decarboxylase 1 (GAD1), γ-aminobutyric
acid (GABA), and GABA receptors are involved in tumor progression. However, the …