Overview of the IL‐1 family in innate inflammation and acquired immunity

CA Dinarello - Immunological reviews, 2018 - Wiley Online Library
Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

The IL-1 family of cytokines and receptors in rheumatic diseases

CA Dinarello - Nature Reviews Rheumatology, 2019 - nature.com
More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

Current understanding of IL-37 in human health and disease

Z Su, X Tao - Frontiers in immunology, 2021 - frontiersin.org
IL-37 is a recently discovered cytokine in the IL-1 family exerting broad protective effects on
inflammatory diseases, autoimmune diseases, and cancer. Immune and non-immune cells …

The interleukin (IL)-1 cytokine family–Balance between agonists and antagonists in inflammatory diseases

J Palomo, D Dietrich, P Martin, G Palmer, C Gabay - Cytokine, 2015 - Elsevier
Abstract The interleukin (IL)-1 family of cytokines comprises 11 members, including 7 pro-
inflammatory agonists (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) and 4 defined or …

Suppression of inflammation and acquired immunity by IL‐37

G Cavalli, CA Dinarello - Immunological reviews, 2018 - Wiley Online Library
IL‐37 is a unique member of the IL‐1 family of cytokines, which functions as a natural
suppressor of inflammatory and immune responses. Immune and non‐immune cells …

Cytokines in psoriasis

J Baliwag, DH Barnes, A Johnston - Cytokine, 2015 - Elsevier
Psoriasis is a common inflammatory skin disease with an incompletely understood etiology.
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …

Interleukin-36–receptor antagonist deficiency and generalized pustular psoriasis

S Marrakchi, P Guigue, BR Renshaw… - … England Journal of …, 2011 - Mass Medical Soc
Background Generalized pustular psoriasis is a life-threatening disease of unknown cause.
It is characterized by sudden, repeated episodes of high-grade fever, generalized rash, and …

Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases

M Akdis, S Burgler, R Crameri, T Eiwegger… - Journal of allergy and …, 2011 - Elsevier
Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

LA Borthwick - Seminars in immunopathology, 2016 - Springer
The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor
antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of …

IL-37 is a fundamental inhibitor of innate immunity

MF Nold, CA Nold-Petry, JA Zepp, BE Palmer… - Nature …, 2010 - nature.com
The function of interleukin 37 (IL-37; formerly IL-1 family member 7) has remained elusive.
Expression of IL-37 in macrophages or epithelial cells almost completely suppressed …