Genetic disruption of mammalian endoplasmic reticulum‐associated protein degradation: Human phenotypes and animal and cellular disease models
Endoplasmic reticulum‐associated protein degradation (ERAD) is a stringent quality control
mechanism through which misfolded, unassembled and some native proteins are targeted …
mechanism through which misfolded, unassembled and some native proteins are targeted …
Midbrain organoids for Parkinson's disease (PD)-A powerful tool to understand the disease pathogenesis
HWS Babu, SM Kumar, H Kaur, M Iyer, B Vellingiri - Life Sciences, 2024 - Elsevier
Abstract Brain Organiods (BOs) are a promising technique for researching disease
progression in the human brain. These organoids, which are produced from human induced …
progression in the human brain. These organoids, which are produced from human induced …
In depth characterization of midbrain organoids derived from wild type iPSC lines
The ability to model human neurological tissues in vitro has been a major hurdle to effective
drug development for neurological disorders. iPSC-derived brain organoids have emerged …
drug development for neurological disorders. iPSC-derived brain organoids have emerged …
Development of a fluorescence and quencher-based FRET assay for detection of endogenous peptide: N-glycanase/NGLY1 activity
H Hirayama, Y Tachida, R Fujinawa, Y Matsuda… - Journal of Biological …, 2024 - ASBMB
Cytosolic peptide: N-glycanase (PNGase/NGLY1 in mammals) catalyzes deglycosylation of
N-glycans on glycoproteins. A genetic disorder caused by mutations in the NGLY1 gene …
N-glycans on glycoproteins. A genetic disorder caused by mutations in the NGLY1 gene …
Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …
Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids
Understanding the impact of long‐term opioid exposure on the embryonic brain is critical
due to the surging number of pregnant mothers with opioid dependency. However, this has …
due to the surging number of pregnant mothers with opioid dependency. However, this has …